Hussam Al-Kateb, MSc, PhD, FACMGG

Associate Professor, Pathology - (Clinical Scholar Track)
Medical Director, University of Arizona Genetic Core for Clinical Services (UAGC-CS) Laboratory
Director, Cytogenomic Laboratory, Banner University Medical Center

Dr. Al-Kateb comes from the Washington University School of Medicine in St. Louis, where he served as Assistant Professor in the Department of Pathology and Immunology for five years. Dr. Al-Kateb’s international training includes a Bachelor’s degree in Pharmacy and Pharmaceutical Chemistry, and a Master’s degree in Clinical Pathology, both from the School of Pharmacy, Damascus University; a Doctorate degree  (summa cum laude) in Human Molecular Genetics from the University of Heidelberg, Germany; post-doctoral fellowship training at the Hospital for Sick Children in Canada; and  fellowship training in both Clinical Cytogenetics and Clinical Molecular Genetics at Case Western Reserve University, Ohio. He is dually boarded by the American Board of Medical Genetics and Genomics (ABMGG) in Clinical Cytogenetics and Clinical Molecular Genetics and Genomics.

Research Interests: 

As Medical Director of the University of Arizona Genetic Core for Clinical Services Laboratory, Dr. Al-Kateb's focus is on developing clinical genetic tests that aim at identifying somatic mutations to be used for cancer targeted therapy, and developing clinical genetic tests that seek to identify germline mutations which underline constitutional genetic disorders using state-of-the art technologies.

Dr. Al-Kateb's has authored more than 56 publications including original articles, abstracts and book chapters. His research interest is in identifying disease genes for both mendelian and complex diseases, genotype-phenotype correlations, identifying genetic markers for cancer and applying NGS technology in the clinic.

Fellowship
  • American College of Medical Genetics and Genomics, 2012
Board Certifications
  • American Society of Human Genetics - 2004
  • International Genetics Epidemiology Society (IGES), 2005-2006
  • American Diabetes Association, 2006-2007
  • Diplomat of the American Board of Medical Genetics and Genomics - 2011
  • College of American Pathologists, Cytogenetics and Molecular Genetics, 2013

Select Publications

2017

Ma, C. X., F. Gao, J. Luo, D. W. Northfelt, M. Goetz, A. Forero, J. Hoog, M. Naughton, F. Ademuyiwa, R. Suresh, et al., "NeoPalAna: Neoadjuvant Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, and Anastrozole for Clinical Stage 2 or 3 Estrogen Receptor-Positive Breast Cancer.", Clin Cancer Res, 2017 Mar 07. PMID: 28270497
Ma, C. X., R. Bose, F. Gao, R. A. Freedman, M. L. Telli, G. Kimmick, E. P. Winer, M. J. Naughton, M. P. Goetz, C. Russell, et al., "Neratinib Efficacy and Circulating Tumor DNA Detection of HER2 Mutations in HER2 Non-amplified Metastatic Breast Cancer.", Clin Cancer Res, 2017 Jul 05. PMID: 28679771

2015

Wu, N., X. Ming, J. Xiao, Z. Wu, X. Chen, M. Shinawi, Y. Shen, G. Yu, J. Liu, H. Xie, et al., "TBX6 null variants and a common hypomorphic allele in congenital scoliosis.", N Engl J Med, vol. 372, issue 4, pp. 341-50, 2015 Jan 22. PMCID: PMC4326244  PMID: 25564734
Hagemann, I. S., S. Devarakonda, C. M. Lockwood, D. H. Spencer, K. Guebert, A. J. Bredemeyer, H. Al-Kateb, TD. T. Nguyen, E. J. Duncavage, C. E. Cottrell, et al., "Clinical next-generation sequencing in patients with non-small cell lung cancer.", Cancer, vol. 121, issue 4, pp. 631-9, 2015 Feb 15. PMID: 25345567
Shinawi, M., R. Coorg, J. S. Shimony, D. K. Grange, and H. Al-Kateb, "Intragenic CAMTA1 deletions are associated with a spectrum of neurobehavioral phenotypes.", Clin Genet, vol. 87, issue 5, pp. 478-82, 2015 May. PMID: 24738973
Al-Kateb, H., TD. T. Nguyen, K. Steger-May, and J. D. Pfeifer, "Identification of major factors associated with failed clinical molecular oncology testing performed by next generation sequencing (NGS).", Mol Oncol, vol. 9, issue 9, pp. 1737-43, 2015 Nov. PMID: 26071350

2014

Al-Kateb, H., G. Khanna, I. Filges, N. Hauser, D. K. Grange, J. Shen, C. D. Smyser, S. Kulkarni, and M. Shinawi, "Scoliosis and vertebral anomalies: additional abnormal phenotypes associated with chromosome 16p11.2 rearrangement.", Am J Med Genet A, vol. 164A, issue 5, pp. 1118-26, 2014 May. PMID: 24458548
Abel, H. J., H. Al-Kateb, C. E. Cottrell, A. J. Bredemeyer, C. C. Pritchard, A. H. Grossmann, M. L. Wallander, J. D. Pfeifer, C. M. Lockwood, and E. J. Duncavage, "Detection of gene rearrangements in targeted clinical next-generation sequencing.", J Mol Diagn, vol. 16, issue 4, pp. 405-17, 2014 Jul. PMCID: PMC4078366  PMID: 24813172
Cottrell, C. E., H. Al-Kateb, A. J. Bredemeyer, E. J. Duncavage, D. H. Spencer, H. J. Abel, C. M. Lockwood, I. S. Hagemann, S. M. O'Guin, L. C. Burcea, et al., "Validation of a next-generation sequencing assay for clinical molecular oncology.", J Mol Diagn, vol. 16, issue 1, pp. 89-105, 2014 Jan. PMID: 24211365

2013

Al-Kateb, H., J. S. Shimony, M. Vineyard, L. Manwaring, S. Kulkarni, and M. Shinawi, "NR2F1 haploinsufficiency is associated with optic atrophy, dysmorphism and global developmental delay.", Am J Med Genet A, vol. 161A, issue 2, pp. 377-81, 2013 Feb. PMID: 23300014
Sharma, M. K., J. Phillips, S. Agarwal, W. S. Wiggins, S. Shrivastava, S. B. Koul, M. Bhattacharjee, C. D. Houchins, R. R. Kalakota, B. George, et al., "Clinical genomicist workstation.", AMIA Jt Summits Transl Sci Proc, vol. 2013, pp. 156-7, 2013. PMID: 24303327

2010

Al-Kateb, H., A. Hahn, J. M. Gastier-Foster, L. Jeng, S. E. McCandless, and C. A. Curtis, "Molecular characterization of a novel, de novo, cryptic interstitial deletion on 19p13.3 in a child with a cutis aplasia and multiple congenital anomalies.", Am J Med Genet A, vol. 152A, issue 12, pp. 3148-53, 2010 Dec. PMID: 21108400

2008

Al-Kateb, H., A. P. Boright, L. Mirea, X. Xie, R. Sutradhar, A. Mowjoodi, B. Bharaj, M. Liu, J. M. Bucksa, V. L. Arends, et al., "Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study.", Diabetes, vol. 57, issue 1, pp. 218-28, 2008 Jan. PMCID: PMC2655325  PMID: 17914031

2007

Al-Kateb, H., L. Mirea, X. Xie, L. Sun, M. Liu, H. Chen, S. B. Bull, A. P. Boright, and A. D. Paterson, "Multiple variants in vascular endothelial growth factor (VEGFA) are risk factors for time to severe retinopathy in type 1 diabetes: the DCCT/EDIC genetics study.", Diabetes, vol. 56, issue 8, pp. 2161-8, 2007 Aug. PMID: 17513698
Meshkani, R., M. Taghikhani, H. Al-Kateb, B. Larijani, S. Khatami, G. Konstantin Sidiropoulos, R. Alexander Hegele, and K. Adeli, "Polymorphisms within the protein tyrosine phosphatase 1B (PTPN1) gene promoter: functional characterization and association with type 2 diabetes and related metabolic traits.", Clin Chem, vol. 53, issue 9, pp. 1585-92, 2007 Sep. PMID: 17634210