Prof. Marty’s research centers on developing new technologies to study interactions at biological membranes, with a special focus on combining lipoprotein nanodiscs and native mass spectrometry. One aspect of his research focuses on characterizing membrane protein-protein and membrane protein-lipid interactions. Membrane proteins are important drug targets, and the Marty lab seeks to understand how lipids influence membrane proteins important in cancer. The second aspect of Prof. Marty’s research focuses on assembly of antimicrobial peptide complexes, which also show anticancer activity. By characterizing the biophysics of peptide interactions with and within lipid bilayers, they seek to shed light on the mechanisms of anticancer peptide toxicity and selectivity.
