Naomi E. Rance, MD, PhD

Research Interests: 
  • Neuroendocrinology: Hypothalamic-pituitary-gonadal axis
  • Changes in morphology and neuropeptide gene expression in the hypothalamus of postmenopausal women
  • Neurokinin B and the hypothalamic regulation of reproduction
  • Effects of estrogen on hypothalamic thermoregulation with the goal of understanding the etiology of menopausal flushes
Degrees
  • PhD: University of Maryland School of Medicine, 1981
  • MD: University of Maryland School of Medicine, 1983
Residency
  • The Johns Hopkins Hospital, Anatomic Pathology, 1983-1986
  • The Johns Hopkins Hospital, Anatomic Pathology, 1986-1987
Fellowship
  • The Johns Hopkins Hospital, Neuropathology, 1987-1989
Board Certifications
  • American Board of Pathology - Neuropathology

Select Publications

2016

Mittelman-Smith, M. A., S. J. Krajewski-Hall, N. T. McMullen, and N. E. Rance, "Ablation of KNDy Neurons Results in Hypogonadotropic Hypogonadism and Amplifies the Steroid-Induced LH Surge in Female Rats.", Endocrinology, vol. 157, issue 5, pp. 2015-27, 2016 May. PMCID: PMC4870865  PMID: 26937713

2015

Cholanian, M., S. J. Krajewski-Hall, N. T. McMullen, and N. E. Rance, "Chronic oestradiol reduces the dendritic spine density of KNDy (kisspeptin/neurokinin B/dynorphin) neurones in the arcuate nucleus of ovariectomised Tac2-enhanced green fluorescent protein transgenic mice.", J Neuroendocrinol, vol. 27, issue 4, pp. 253-63, 2015 Apr. PMCID: PMC4788980  PMID: 25659412
Mittelman-Smith, M. A., S. J. Krajewski-Hall, N. T. McMullen, and N. E. Rance, "Neurokinin 3 Receptor-Expressing Neurons in the Median Preoptic Nucleus Modulate Heat-Dissipation Effectors in the Female Rat.", Endocrinology, vol. 156, issue 7, pp. 2552-62, 2015 Jul. PMCID: PMC4475724  PMID: 25825817

2014

Cholanian, M., S. J. Krajewski-Hall, R. B. Levine, N. T. McMullen, and N. E. Rance, "Electrophysiology of arcuate neurokinin B neurons in female Tac2-EGFP transgenic mice.", Endocrinology, vol. 155, issue 7, pp. 2555-65, 2014 Jul. PMCID: PMC4060187  PMID: 24735328

2013

Rance, N. E., P. A. Dacks, M. A. Mittelman-Smith, A. A. Romanovsky, and S. J. Krajewski-Hall, "Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes.", Front Neuroendocrinol, vol. 34, issue 3, pp. 211-27, 2013 Aug. PMCID: PMC3833827  PMID: 23872331

2012

Mittelman-Smith, M. A., H. Williams, S. J. Krajewski-Hall, J. Lai, P. Ciofi, N. T. McMullen, and N. E. Rance, "Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight.", Endocrinology, vol. 153, issue 6, pp. 2800-12, 2012 Jun. PMCID: PMC3359616  PMID: 22508514
Mittelman-Smith, M. A., H. Williams, S. J. Krajewski-Hall, N. T. McMullen, and N. E. Rance, "Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature.", Proc Natl Acad Sci U S A, vol. 109, issue 48, pp. 19846-51, 2012 Nov 27. PMCID: PMC3511761  PMID: 23150555

2011

Dacks, P. A., S. J. Krajewski, and N. E. Rance, "Activation of neurokinin 3 receptors in the median preoptic nucleus decreases core temperature in the rat.", Endocrinology, vol. 152, issue 12, pp. 4894-905, 2011 Dec. PMCID: PMC3230049  PMID: 22028440

2010

Krajewski, S. J., M. C. Burke, M. J. Anderson, N. T. McMullen, and N. E. Rance, "Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat.", Neuroscience, vol. 166, issue 2, pp. 680-97, 2010 Mar 17. PMCID: PMC2823949  PMID: 20038444
Rance, N. E., S. J. Krajewski, M. A. Smith, M. Cholanian, and P. A. Dacks, "Neurokinin B and the hypothalamic regulation of reproduction.", Brain Res, vol. 1364, pp. 116-28, 2010 Dec 10. PMCID: PMC2992576  PMID: 20800582

2009

Rance, N. E., "Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback.", Peptides, vol. 30, issue 1, pp. 111-22, 2009 Jan. PMCID: PMC2632595  PMID: 18614256

2007

Rometo, A. M., S. J. Krajewski, M. Lou Voytko, and N. E. Rance, "Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys.", J Clin Endocrinol Metab, vol. 92, issue 7, pp. 2744-50, 2007 Jul. PMID: 17488799

2006

Burke, M. C., P. A. Letts, S. J. Krajewski, and N. E. Rance, "Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleus.", J Comp Neurol, vol. 498, issue 5, pp. 712-26, 2006 Oct 10. PMID: 16917850

2005

Krajewski, S. J., M. J. Anderson, L. Iles-Shih, K. J. Chen, H. F. Urbanski, and N. E. Rance, "Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence.", J Comp Neurol, vol. 489, issue 3, pp. 372-86, 2005 Aug 29. PMID: 16025449

1991

Rance, N. E., and W. S. Young, "Hypertrophy and increased gene expression of neurons containing neurokinin-B and substance-P messenger ribonucleic acids in the hypothalami of postmenopausal women.", Endocrinology, vol. 128, issue 5, pp. 2239-47, 1991 May. PMID: 1708331