Arthur R. Brothman, Ph.D., FACMG

Professor of Pathology
Director of Cytogenomics
Adjunct Professor, Pediatrics, Human Genetics and Pathology, University of Utah

Office Address: 

University of Arizona Health Sciences Center
LSN-549
PO Box 245043
Tucson, AZ  85724-5043

Office Phone Number: 
(520) 626-5669
Training: 

1974 – 1978    B.S. University of Arizona (General Biology) Tucson, AZ
1978 – 1980    M.S. University of Arizona (Genetics) Tucson, AZ
1980 – 1982    Ph.D. University of Arizona (Genetics) Tucson, AZ
1982 – 1984    Fellow, Columbia University, College of Physicians and Surgeons (Human Genetics and Development) New York, NY
1984 – 1986    Fellow, Los Alamos National Laboratory (Experimental Pathology Group) Los Alamos, NM

Expertise: 

Board Certification: American Board of Medical Genetics, subspecialty, Clinical Cytogenetics: 1987
Associate Editor, Cancer Genetics

Research Interests: 

Cytogenetic and molecular aspects of human prostatic cancer
Molecular analyses including in-situ hybridization (FISH)
Comparative Genomic Hybridization (CGH)
Cytogenomic Microarrays (CMA)

Professional Service: 

Reviewer, NIH, DRG, Special Rev. Committees (1989-present); Path. B Study Section (1994-present ad hoc)
Founding Fellow, American College of Medical Genetics (ACMG)/Diplomate, American Board of Medical Genetics
Member, ACMG/Col. of Am. Path. Cytogenetics Resource Committee, 1996-2002 (Vice-Chair 1999-2002), 2007-2012
Co-Chair, ACMG Quality Assurance Committee (1999-2002)
Member, Institutional Review Group, American Cancer Society (2001-2006)

Selected Publications

Bauer C, Dunn BG, Brothman AR, Dick EJ Jr, Christensen C, Boges A, Moore CM. Polyostotic fibrous dysplasia in a cynomolgus macaque (Macaca fascicularis). Comp Med 62(2):142-8, 2012.

Paxton, C, Brothman AR, Geiersbach, K.  Rapid Aneuploidy Detection in Products of Conception Using the KaryoLite™ BACs-on-Beads™ Assay. Prenatal Diagnosis (in press).

Gu G and Brothman AR.  Cytogenomic aberrations associated with prostate cancer.  Cancer Genetics  204:57-67, 2011.

Yamada NA, Rector LS,  Tsang P, Carr E, Scheffer A , Sederberg, MC,  Aston ME,  Ach RA,  Tsalenko  A,  Sampas N, Peter B,  Bruhn L,  Brothman AR.  Visualization of Fine-Scale Genomic Structure by Oligonucleotide-Based High Resolution FISH. Cytogenet Gen Res 132(4): 248-254, 2011.

South ST and Brothman AR.  Clinical laboratory implementation of cytogenomic microarrays.  Cytogenet and Genome  Res 135:203-211,2011.

Miller DT, Adam MP, Aradhya S, Biesecker LG, Brothman AR, Carter NP, et. al.  Consensus statement: chromosomal  microarray is a first-tier clinical  diagnostic test for individuals with developmental disabilities or congenital anomalies.  Am J Hum Genet.;86(5):749-64,2010.

Brothman AR, Persons DL, Shaffer LG.  Nomenclature evolution: Changes in the ISCN from the 2005 to the 2009 edition. Cytogenet Genome Res.;127(1):1-4, 2009.

Tsuchiya KD, Shaffer LG, Aradhya S, Gastier-Foster JM, Patel A, Rudd MK, Biggerstaff JS, Sanger WG, Schwartz S, Tepperberg JH, Thorland EC, Torchia BA, Brothman AR.  Variability in interpreting and reporting copy number   changes detected by array-based technology in clinical laboratories.  Genet Med.;11(12):866-73, 2009.

Warren JE, Turok DK, Maxwell TM, Brothman AR, Silver RM. Array comparative genomic hybridization for genetic evaluation of fetal loss between 10 and 20 weeks of gestation. Obstet Gynecol;114(5):1093-102, 2009.

Curry C, Mao R, Aston E, Mongia SK, Treisman T, Procter, M, Chou B, Whitby H, South ST, Brothman AR.  Homozygous Deletions of a Copy Number Change detected by array CGH: A New Cause for Mental Retardataion?  Am J Med Genet, 146A(15),1903-1920, 2008.