Lisa Rimsza, M.D.

Professor of Pathology
Associate Chair of Research
 

Office Address: 

1501 N. Campbell, Room 5208A
 PO Box 245043
 Tucson, Arizona  85724
 

Office Phone Number: 
(520) 626-8396
Lab Phone Number: 
(520) 626-7894
Fax: 
(520) 626-6081
Lab Affiliation: 
Rimsza Lab
Training: 

Dr. Rimsza received her medical degree from the University of Arizona in Tucson.  She completed Anatomic and Clinical Pathology residency training at the University of Arizona and her two-year fellowship in Hematopathology at the University of New Mexico in Albuquerque.

Expertise: 

Dr. Rimsza is board certified by the American Board of Pathology in Anatomic and Clinical Pathology and subspecialty certified in Hematology.

Research Interests: 

As a long term member and current principle investigator of the international collaborative group, the Leukemia and Lymphoma Molecular Profiling Project, Dr. Rimsza is involved with development of new molecular methods, including gene expression profiling in frozen and paraffin embedded tissues, for lymphoma diagnosis and prognosis. She also directs the Arizona Lymphoma Repository and collaborates with the biotech industry on new test development. Dr. Rimsza is currently the Chair of the Southwest Oncology Lymphoma Translational Medicine Subcommittee, working closely with the lymphoma physicians on new treatment strategies for patients.  Her primary research focuses on the biology of diffuse large B cell lymphoma, particularly the investigation of prognostic biomarkers and mechanisms of lost tumor immunosurveillance. She also has collaborative research projects in the field of neonatal thrombocytopenia.

Professional Service: 

Dr. Rimsza works as a diagnostic Hematopathologist, is the Director of Flow Cytometry, and the Directory of the Molecular Genetic Pathology Fellowship at the University Medical Center.

Selected Publications

Nitta H, Zhang W, Kelly BD, Miller M, Pestic-Dragovich L, Bieniarz C, Vasicek TJ, Marafioti T, Rimsza L, Grogan TM. Automated brightfield break-apart in situ hybridization (ba-ISH) application: ALK and MALT1 genes as models. Methods 2010 Dec;52(4):352-8.
20621192
 
Stasik CJ, Nitta H, Zhang W, Mosher CH, Cook JR, Tubbs RR, Unger JM, Brooks TA, Persky DO, Wilkinson ST, Grogan TM, Rimsza LM. Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma. Haematologica 2010 April;95(4):597-603.
20378577
 
Rimsza LM, Chan WC, Gascoyne RD, Campo E, Jaffe ES, Staudt LM, Delabie J, Rosenwald A, Murphy SP. CIITA or RFX coding region loss of function mutations occur rarely in diffuse large B-cell lymphoma cases and cell lines with low levels of major histocompatibility complex class II expression. Haematologica 2009 Apr;94(4):596-8.
19229048
 
Rimsza LM, Lenz G, Wright G, Dave SS, Xiao W, Powell J, Zhao H, Xu W, Tan B, Goldschmidt N, Iqbal J, Vose J, Bast M, et al. Lymphoma/Leukemia Molecular Profiling Project. Stromal gene signatures in large-B-cell lymphomas. N Engl J Med 2008 Nov 27;359(22):2313-23.
19038878
 
Rimsza LM, LeBlanc ML, Unger JM, Miller TP, Grogan TM, Persky DO, Martel RR, Sabalos CM, Seligmann B, Braziel RM, et al. Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP. Blood 2008 Oct 15;112(8):3425-33.
18544678
Roberts RA, Sabalos CM, LeBlanc ML, Martel RR, Frutiger YM, Unger JM, Botros IW, Rounseville MP, Seligmann BE, Miller TP, Grogan TM, Rimsza LM. Quantitative nuclease protection assay in paraffin-embedded tissue replicates prognostic microarray gene expression in diffuse large-B-cell lymphoma. Lab Invest 2007 Oct;87(10):979-97.
17700562
 
Sola-Visner MC, Christensen RD, Hutson AD, Rimsza LM. Megakaryocyte size and concentration in the bone marrow of thrombocytopenic and non-thrombocytopenic neonates. Pediatr Res 2007 Apr;61(4):479-84.
17515875
 
Rimsza LM, Roberts RA, Campo E, Grogan TM, Bea S, Salaverria I, Zettl A, Rosenwald A, Ott G, Muller-Hermelink K, et al. Loss of major histocompatibility class II expression in non-immune-privileged site diffuse large B-cell lymphoma is highly coordinated and not due to chromosomal deletions. Blood 2006 Feb 1;107(3):1101-7.
16239429
 
Saxonhouse MA, Sola MC, Pastos KM, Ignatz ME, Hutson AD, Christensen RD, Rimsza LM. Reticulated platelet percentages in term and preterm neonates. J Pediatr Hematol Oncol 2004 Dec;26(12):797-802.
15591898
 
Rimsza LM,Douglas VK, Tighe P, Saxonhouse MA, Calhoun DA, Christensen RD, Sola MC. Benign B-cell precursors (hematogones) are the predominant lymphoid population in the bone marrow of preterm infants. Biol Neonate 2004;86(4):247-53.
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