Support the Department of Pathology

Naomi E. Rance, M.D., Ph.D.

Professor and Associate Head

Office Address: 

1501 N. Campbell Avenue
LSN 547
PO Box 245043
Tucson, AZ  85724-5043

Office Phone Number: 
(520) 626-6099
Lab Phone Number: 
(520) 626-5506
(520) 626-1027
Lab Affiliation: 
Rance Lab

1981 - Ph.D., Physiology Department, University of Maryland School of Medicine
1983 - M.D., University of Maryland School of Medicine
1983 - 1986  Resident, Anatomic Pathology, The Johns Hopkins Hospital                                   
1986 - 1987  Chief Resident, Anatomic Pathology, The Johns Hopkins Hospital
1987 - 1989  Fellow, Neuropathology, The Johns Hopkins Hospital


Surgical and Autopsy Neuropathology

Research Interests: 
  • Neuroendocrinology: Hypothalamic-pituitary-gonadal axis
  • Changes in morphology and neuropeptide gene expression in the hypothalamus of postmenopausal women
  • Neurokinin B and the hypothalamic regulation of reproduction
  • Effects of estrogen on hypothalamic thermoregulation with the goal of understanding the etiology of menopausal flushes
Professional Service: 

Teaching Neuropathology to medical students and residents.

Selected Publications

Rance NE Krajewski SJ, Smith MA, Cholanian M, Dacks PA. Neurokinin B and the hypothalamic regulation of reproduction. Special issue entitled “New Insights into the Neurobiology of Reproduction and Puberty”. Brain Res 2010 Dec 10;1364:116-28 
Williams H, Dacks PA, Rance NE. An improved method for recording tail skin temperature in the rat reveals changes during the estrous cycle and effects of ovarian steroids. Endocrinology 2010 Nov;151(11):5389-94
Rometo AM, Krajewski SJ, Voytko ML, Rance NE. Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J Clin Endocrinol Metab 2007 Jul;92(7):2744-50
Burke MC, Letts PA, Krajewski SJ, Rance NE. Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleus. J Comp Neurol 2006 Oct 10;498(5):712-26
Krajewski SJ, Anderson Miranda J, Iles-Shi L, Chen Kyung J, Urbanski HF, Rance NE. Morphological evidence that neurokinin B modulates GnRH secretion via neurokinin3 receptors in the rat median eminence. J Comp Neurol 2005 Aug 29;489(3):372-86
Sandoval-Guzmán T, Stalcup ST, Krajewski SJ, Voytko ML, Rance NE. Effects of ovariectomy on the neuroendocrine axes regulating reproduction and energy balance in young cynomolgus macaques. J Neuroendocrinol 2004 Feb;16(2):146-53
Abel TW, Rance NE. Stereological study of the hypothalamic infundibular nucleus in young and older women. J Comp Neurol 2000 Sep 4;424(4):679-88
Abel TW, Voytko ML, Rance NEThe effects of hormone replacement therapy on hypothalamic neuropeptide gene expression in a primate model of menopause. J Clin Endocrinol Metab 1999 Jun;84(6):2111-8
Danzer SC, McMullen NT, Rance NE. Dendritic growth of arcuate neuroendocrine neurons following orchidectomy in adult rats. J Comp Neurol 1998 Jan 12;390(2):234-46  
Rance NE, Uswandi SV. Gonadotropin-releasing hormone gene expression is increased in the medial basal hypothalamus of postmenopausal women. J Clin Endocrinol Metab 1996 Oct;81(10):3540-46