The Laboratory of Dr. Briehl
Dr. Briehl’s laboratory's is investigating the mechanisms by which the redox state of cancer cells causes resistance to therapy-induced apoptosis. Cellular redox state is determined by the sum of prooxidants (e.g., the levels of reactive oxygen species) and antioxidants (e.g., proteins like catalase and small molecules like vitamin E) in the cell. Cancer cells have frequently undergone changes consistent with an altered ability to handle oxidative stress. Genetic differences in proteins that protect cells against oxidative stress have been associated with an increased risk of cancer.
