Naomi E Rance, MD, PhD

Professor Emerita, Pathology

Professor, Cellular and Molecular Medicine

Professor, Neurology

Professor, Evelyn F McKnight Brain Institute

547

(520) 626-6099

nrance@arizona.edu

Links

Full Publication List

Residency

The Johns Hopkins Hospital, Anatomic Pathology, 1983-1986
The Johns Hopkins Hospital, Anatomic Pathology, 1986-1987

Degrees

PhD: University of Maryland School of Medicine, 1981
MD: University of Maryland School of Medicine, 1983

Fellowship

The Johns Hopkins Hospital, Neuropathology, 1987-1989

Awards

Founders Day Award, University of Arizona College of Medicine, 2015
Vernon and Virginia Furrow Award for Excellence in Innovation in Teaching, University of Arizona College of Medicine, 2007
Faculty Marshall, Medical School Convocation University of Arizona College of Medicine, 2004
Basic Science Educator of the Year Lifetime Award, University of Arizona College of Medicine, 2002
Basic Sciences Educator of the Year, University of Arizona College of Medicine, 2001

Licensure & Certification

American Board of Pathology - Neuropathology

Research Interests

Neuroendocrinology: Hypothalamic-pituitary-gonadal axisChanges in morphology and neuropeptide gene expression in the hypothalamus of postmenopausal womenNeurokinin B and the hypothalamic regulation of reproductionEffects of estrogen on hypothalamic thermoregulation with the goal of understanding the etiology of menopausal flushes

Publications

Kambhampati M, Panditharatna E, Yadavilli S, et al. Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas. Scientific Reports. 2020;10(1). doi:10.1038/s41598-020-67764-2

Coborn JE, Lessie RE, Sinton CM, Rance NE, Perez-Leighton CE, Teske JA. Noise-induced sleep disruption increases weight gain and decreases energy metabolism in female rats. International Journal of Obesity. 2018;43(9):1759–1768. doi:10.1038/s41366-018-0293-9

Krajewski-Hall SJ, Blackmore EM, McMinn JR, Rance NE. Estradiol alters body temperature regulation in the female mouse. Temperature. 2017;5(1):56–69. doi:10.1080/23328940.2017.1384090

Mittelman-Smith MA, Krajewski-Hall SJ, McMullen NT, Rance NE. Ablation of KNDy Neurons Results in Hypogonadotropic Hypogonadism and Amplifies the Steroid-Induced LH Surge in Female Rats. Endocrinology. 2016;157(5):2015–2027. doi:10.1210/en.2015-1740

Mittelman-Smith MA, Krajewski-Hall SJ, McMullen NT, Rance NE. Neurokinin 3 Receptor-Expressing Neurons in the Median Preoptic Nucleus Modulate Heat-Dissipation Effectors in the Female Rat. Endocrinology. 2015;156(7):2552–2562. doi:10.1210/en.2014-1974

Cholanian M, Krajewski-Hall SJ, Levine RB, McMullen NT, Rance NE. Electrophysiology of Arcuate Neurokinin B Neurons in Female Tac2-EGFP Transgenic Mice. Endocrinology. 2014;155(7):2555–2565. doi:10.1210/en.2014-1065

Rance NE, Dacks PA, Mittelman-Smith MA, Romanovsky AA, Krajewski-Hall SJ. Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes. Frontiers in Neuroendocrinology. 2013;34(3):211–227. doi:10.1016/j.yfrne.2013.07.003

Mittelman-Smith MA, Williams H, Krajewski-Hall SJ, McMullen NT, Rance NE. Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature. Proceedings of the National Academy of Sciences. 2012;109(48):19846–19851. doi:10.1073/pnas.1211517109

Dacks PA, Krajewski SJ, Rance NE. Activation of Neurokinin 3 Receptors in the Median Preoptic Nucleus Decreases Core Temperature in the Rat. Endocrinology. 2011;152(12):4894–4905. doi:10.1210/en.2011-1492

Rance NE, Krajewski SJ, Smith MA, Cholanian M, Dacks PA. Neurokinin B and the hypothalamic regulation of reproduction. Brain Research. 2010;1364:116–128. doi:10.1016/j.brainres.2010.08.059

Rance NE. Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback. Peptides. 2009;30(1):111–122. doi:10.1016/j.peptides.2008.05.016

Rometo AM, Krajewski SJ, Lou Voytko M, Rance NE. Hypertrophy and Increased Kisspeptin Gene Expression in the Hypothalamic Infundibular Nucleus of Postmenopausal Women and Ovariectomized Monkeys. The Journal of Clinical Endocrinology & Metabolism. 2007;92(7):2744–2750. doi:10.1210/jc.2007-0553

Burke MC, Letts PA, Krajewski SJ, Rance NE. Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleus. Journal of Comparative Neurology. 2006;498(5):712–726. doi:10.1002/cne.21086

Krajewski SJ, Anderson MJ, Iles‐Shih L, Chen KJ, Urbanski HF, Rance NE. Morphologic evidence that neurokinin B modulates gonadotropin‐releasing hormone secretion via neurokinin 3 receptors in the rat median eminence. Journal of Comparative Neurology. 2005;489(3):372–386. doi:10.1002/cne.20626

Rance NE, YOUNG WS. Hypertrophy and Increased Gene Expression of Neurons Containing Neurokinin-B and Substance-P Messenger Ribonucleic Acids in the Hypothalami of Postmenopausal Women*. Endocrinology. 1991;128(5):2239–2247. doi:10.1210/endo-128-5-2239

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